The game opens in 1499 immediately after the end of Assassin's Creed II, and centers around Ezio Auditore's continuing conflict against the power-hungry Borgia family in Rome at the time of the early Italian Wars, and his efforts to restore the local Assassin Brotherhood to its former glory.
Assassin's Creed: Brotherhood is the third chronological game in the Assassin's Creed series, and is the first main game to not be a numbered sequel, released in 2010 on PlayStation 3, Xbox 360 (playable on Xbox One via backward compatibility), and PC, as well as in 2016 on PlayStation 4 and Xbox One via The Ezio Collection.